Looking for cheap flights from Chicago O'Hare to Greenville? FareFort™ helps you compare real-time fares across top airlines and booking sites. Live prices for 2025-12-10 → 2025-12-17 are displayed below.
The Chicago O'Hare–Greenville route connects two major travel hubs. Average flight time is approximately Varies by route, with several daily nonstop and connecting options. Major airlines include Multiple airlines.